Table 1.

Results of individual participant data meta-analysis [10]

Models	Carotid DC (per 1 lower SD) as the determinant and incident stroke as the outcome1
Cox regression analysis	Hazard ratio (95% confidence interval)
Model 12	1.24 (1.05; 1.47)
Model 12 + cfPWV	1.24 (1.05; 1.46)
Risk improvement analysis3	Effect estimate (95% confidence interval)
IDI, % point	0.4 (0.1; 0.6)
Continuous NRI, %	18.6 (5.8; 31.3)

Association between carotid stiffness and incident stroke: additional adjustments for cfPWV and analysis of risk improvement. The model was extended by the carotid distensibility coefficient (DC). SD = Standard deviation; IDI = integrated discrimination improvement; NRI = net reclassification index.

¹Number of participants for this analysis: n = 4,075, with 351 events and 47,881 person-years of follow-up.

²Model 1: results adjusted for age, sex, mean arterial pressure, heart rate, body mass index, smoking habits, diabetes, triglycerides, total/high-density lipoprotein cholesterol ratio, prior cardiovascular disease, and the use of lipid-modifying and antihypertensive medication.

³The baseline model for risk improvement analysis included the Framingham stroke risk score factors and cfPWV.