Table 2.

Characteristics of trials that compared intensive with less intensive blood pressure lowering

First author or acronym [ref.]	Year of publication	Total number of subjects	Entry criteria of age, years	Patients	Treatment or goal BP	Comment
Intensive vs. less intensive BP lowering without defined goals
ADVANCE [21]	2007	11,140	>55 Hypertension and type 2 DM	Perindopril/indapamide combination vs. placebo	No evidence of J-curve
NAVIGATOR [29]	2010	9,306	>50	CAD, CV risk factors or impaired glucose tolerance	Valsartan vs. placebo	Valsartan led to a 21% reduction in the incidence of stroke but did not reduce the rate of CV events
ROADMAP [22]	2011	4,447	18–75	Hypertension and type 2 DM	Olmesartan vs. placebo	Among patients with pre-existing CAD, those in the lowest quartile of SBP and those in the highest quartile of SBP reduction during the double-blind treatment had the highest rates of CV disease
Intensive vs. less intensive BP lowering with defined goals
ACCORD-BP [19]	2007	4,733	>55	Hypertension and type 2 DM	SBP <120 vs. <140 mm Hg	No significant difference
JATOS [17]	2008	4,418	65–85	Hypertensive patients	SBP <130 vs. <140 mm Hg	No significant difference
VALISH [18]	2010	3,260	70–84	Isolated systolic hypertension	SBP >140 to <150 vs. <140 mm Hg	No significant difference
INTERACT2 [31, 32]	2013	2,839	Mean 63.2	ICH and SBP 150–220 mm Hg	Intensive (<140 mm Hg) vs. less intensive BP lowering	Intensive BP lowering better
SPRINT [20]	2015	9,361	>50	Hypertension with an increased CV risk and without DM or a history of stroke	SBP <120 vs. <140 mm Hg	SBP <120 mm Hg better

BP = Blood pressure; CAD = coronary artery disease; CV = cardiovascular; DM = diabetes mellitus; ICH = intracerebral hemorrhage; SBP = systolic blood pressure.