Table 1. Effect of caloric restriction and high fat diet during 3 months on % fat mass, % lean mass, body weight gain, and plasma glucose, insulin, leptin and triglycerides levels.

	CR	ND	HFD
Fat mass (%)	2.1 ± 0.6 a	9.5 ± 0.5 b	18.8 ± 0.9 c
Lean mass (%)	80.3 ± 0.7 a	73.1 ± 0.7 b	66.2 ± 0.8 c
Body weight gain (g)	173.2 ± 4.8 a	306.8 ± 9.0 b	362.0 ± 7.3 c
Glucose (mg/dl)	72.0 ± 1.4 a	78.44 ± 1.0 b	139.3 ± 4.0 c
Insulin (ng/ml)	1.01 ± 0.1 a	3.2 ± 0.3 b	4.1 ± 0.3 c
Leptin (ng/ml)	3.3 ± 0.6 a	8.5 ± 1.0 b	15.7 ± 0.8 c
Tryglicerides (mg/dl)	64.1 ± 3.9 a	120.8 ± 6.2 b	148.1 ± 8.3 c

Values are expressed as mean ± SEM. Different letters indicate statistical differences (One-way ANOVA with post hoc Tukey test, a value of P < 0.05 was considered statistically significant). CR: caloric restriction (n = 10), ND: normal diet (n = 10) and HFD: high fat diet (n = 10). The animals were reared in these diets during three months after weaning.