Table 1. Oxidative stress parameters and proinflammatory markers in the striatum of 3-nitropropionic acid (3NP)-treated mice.
| ROUP | COX-2 (2expΔΔct) | TNF-α (2expΔΔct) | IL-6 (2expΔΔct) | %Catalase activity | % GSH | % SOD activity |
|---|---|---|---|---|---|---|
| VEH | 1.25 ± 0.68 | 1.03 ± 0.226 | 1.2 ± 0.4 | 100 | 100 | 100 |
| 3NP | 4.69 ± 0.09* | 5.19 ± 0.327** | 4.28 ± 0.08* | 58.85 ± 2.17*** | 67.16 ± 5.06 | 56.56 ± 1.05** |
| VCE-003.2 | 1.31 ± 0.75 | 1.15 ± 058 | 1.14 ± 0.65 | 99.05 ± 6.1 | 101.81 ± 14.59 | 115.62 ± 27.34 |
| 3NP + VCE-003.2 | 2.7 ± 0.07### | 1.56 ± 0.576## | 1.79 ± 0.2### | 88.82 ± 6.75# | 111.7 ± 12.6 | 221.18 ± 26.91# |
| 3NP + VCE-003.2 + T0070907 | 8.91 ± 1† | 3.83 ± 1.17 | 8.18 ± 2.9 | 89.08 ± 5.7 | 121.48 ± 15.29 | 121.46 ± 37.04 |
| T0070907 | 1.45 ± 0.82 | 1.54 ± 0.75 | 1.57 ± 0.51 | 92.18 ± 4.1 | 115.82 ± 11.23 | 97.61 ± 27.44 |
Data presented are the percentage of the vehicle-treated control group and are expressed as means ± SEM (n = 6 animals per group). Statistics: *p < 0.05, **p < 0.01, ***p < 0.001 versus Vehicle; #p < 0.05, ##p < 0.01, ###p < 0.001 versus 3NP; †p < 0.05 versus the 3NP + VCE-003.2 group.