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. 2016 Jul 19;6:29712. doi: 10.1038/srep29712

Figure 1. CD137L-DCs have a transcriptomic signature most similar to that of immature cDCs and macrophages.

Figure 1

Monocytes from 5 healthy donors were differentiated to the various APC subsets. RNA from fresh monocytes and day 7 APC were used for gene expression profiling by Illumina Human HT12-V4 Expression BeadChip arrays. (A) Hierarchical clustering of genome wide expression profile based on Pearson linkage and (B) principal component analysis. The different APC populations are encircled and represented by different colours. Brown, green, blue, red, black and magenta represent the monocytes, macrophages, imm cDC, mat cDCs, Fc-treated monocytes, and CD137L-DCs, respectively. Principal components (PC) with maximum data variance were selected as representative axis. PC1 and PC2 represent 94% and 1.89% data variance, respectively.