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. 2016 Jul 19;6:29694. doi: 10.1038/srep29694

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) The set of 29 heterologous and endogenous products considered in this study, overlaid on the native metabolic pathways of S. cerevisiae. Only the central metabolic pathways and metabolites relevant for these products are shown. The compounds are grouped according to their industrial use: drug precursors, flavor or aroma compounds, biofuels, and biopolymer precursors. (B) The heterologous pathways consume (black) and produce (red) compounds of the native metabolism. These pathways draw precursors as well as energy and redox cofactors from the native metabolism, in which the byproducts re-enter. Shown is the clustering of products according to these interactions with the yeast native metabolism.