Table I.
Reported cases of EBS symptoms treated with botulinum toxin
| Study | Age, y | Location | Dosing regimen∗ | Time to effect | Total treatments | Duration of effect | Course |
|---|---|---|---|---|---|---|---|
| Abitbol and Zhou1 | 43 | Right foot | Botox (100 U to 1 foot) | 2 wk | 1 | Unknown | Reduction in blistering and surface area involvement |
| Swartling et al2 | 7 | Feet | Dysport (170-250 U) | Unknown | 3 | 4 mo | Improvement in callosities/pedal pain; blister formation unchanged |
| Swartling et al2 | 46 | One foot | Dysport (300 U) | Unknown | 1 | 3 mo | Improvement in callosities/pedal pain/blister formation |
| Swartling et al2 | 30 | One foot | Dysport (300 U) | Unknown | 1 | — | No response to treatment |
| Swartling et al2 | 46 | Feet | Dysport (576-600 U) | Unknown | 3 | 3 mo | Callosities/blister formation/pedal pain much improved |
| Swartling et al2 | 33 | One foot | Dypsort (315 U) | Unknown | 1 | 3 mo | Callosities/blister formation improved; pedal pain not improved |
| Swartling et al2 | 24 | Feet | Dysport (580-700 U) | Unknown | 4 | 3.5 mo | Blister formation/pedal pain improved; callosities not improved |
| Current study | 6 | Feet | Botulinum toxin (50 U; 100 U total) | 2 wk | 2 | 3 mo | Significant improvement with fewer, smaller blisters/decreased pedal pain and odor |
∗
Botox is manufactured by Allergan, Parsippany, NJ. Dysport is manufactured by Galderma, Fort Worth, TX.