Figure 1.

Intermittent PTH increases bone blood flow acutely in BALB/c mice. (a) Representative images of the mouse hind limb perfusion, obtained by laser Doppler imaging (LDI). Images acquired 10 min after administration of vehicle, PTH 1–34 (80μg/kg), L‐NAME (30 mg/kg) or the combination PTH + L‐NAME. The colours in the heat maps indicate the maximum (red) and the minimum (blue) level of perfusion expressed in arbitrary units representing the total blood flux (combination of velocity and concentration of red blood cells). (b) Time course graph of the average hind limb perfusion monitored by LDI for PTH and L‐NAME, alone or in combination. Arrows: 1—Vehicle or L‐NAME injection; 2—vehicle or PTH. Values are presented as means ± standard errors of the mean (S.E.M.); n = 10–14 mice/group; *P < 0.05 versus Control; *** P < 0.001 versus Control