Table 1.

MicroCT analysis of femoral mid‐diaphysis cortical bone and distal metaphysis trabecular bone. Femora were dissected at the end of the 28‐day dosing and analysed by micro‐CT. Bone parameters are shown for the four treatment groups (n = 7–8 mice/group): Vehicle (control), iPTH, iPTH + L‐NAME and L‐NAME alone

Cortical bone parameters	Control	iPTH	iPTH + L‐NAME	L‐NAME
Tissue volume, TV (mm3)	0.028 ± 0.001	0.030 ± 0.001	0.028 ± 0.001	0.029 ± 0.001
Cross‐sectional tissue area, Tt.Ar (mm2)	0.105 ± 0.009	0.112 ± 0.004	0.107 ± 0.004	0.107 ± 0.007
Cross‐sectional bone area, Ct.Ar (mm2)	0.064 ± 0.005	0.072 ± 0.003a	0.068 ± 0.002	0.066 ± 0.005
Imax (mm4)	0.23 ± 0.04	0.27 ± 0.03	0.24 ± 0.02	0.24 ± 0.03
Imin (mm4)	0.10 ± 0.02	0.12 ± 0.01a	0.11 ± 0.01	0.11 ± 0.01
Ipol (mm4)	0.0016 ± 0.0003	0.0019 ± 0.0001a	0.0017 ± 0.0001	0.0017 ± 0.0002
vBMD (g/cm3)	1.269 ± 0.017	1.278 ± 0.010	1.276 ± 0.013	1.279 ± 0.010
Cortical porosity (%)	0.04 ± 0.02	0.04 ± 0.05	0.02 ± 0.03	0.05 ± 0.05
Trabecular bone parameters	Control	iPTH	iPTH + L‐NAME	L‐NAME
Trabecular space, Tb.Sp (mm)	0.18 ± 0.01b	0.21 ± 0.01a, b, c	0.23 ± 0.01a, c	0.19 ± 0.01b
Trabecular pattern factor, Tb.Pf (mm−1)	20.9 ± 2.5b	21.3 ± 1.8b	24.5 ± 2.2a	22.7 ± 1.9
Connectivity density, Conn.D (mm‐3)	290.4 ± 35.5b	183.4 ± 25.0a, b, c	144.8 ± 18.6a, c	273.7 ± 37.7b

Values are mean ± SD;

^a P < 0.05 versus control;

^b P < 0.05 versus iPTH + L‐NAME;

^c P < 0.05 versus L‐NAME.