Table 1.
Changes in arterial blood pressure and heart rate following mustard oil application to the contralateral MG, snout or ipsilateral MT joints
| Site of application | No drug (control) group | RX 821002 treatment group | ||
|---|---|---|---|---|
| Pre‐mustard | Post‐mustard | Pre‐mustard | Post‐mustard | |
| Contralateral MG | ||||
| 1st application | ||||
| BP (mmHg) | 84 ± 7 | 93 ± 6a | 94 ± 4 | 97 ± 3a |
| HR (bpm) | 269 ± 9 | 288 ± 9a | 297 ± 9 | 308 ± 7a |
| 2nd application | ||||
| BP (mmHg) | 80 ± 4 | 87 ± 5a | 86 ± 4 | 89 ± 5a |
| HR (bpm) | 286 ± 8 | 294 ± 7a | 305 ± 9 | 309 ± 8 |
| Snout | ||||
| 1st application | ||||
| BP (mmHg) | 80 ± 5 | 109 ± 6a | 87 ± 3 | 113 ± 3a |
| HR (bpm) | 273 ± 7 | 285 ± 5a | 299 ± 12 | 308 ± 9a |
| 2nd application | ||||
| BP (mmHg) | 74 ± 6 | 94 ± 6a | 85 ± 6 | 99 ± 7a |
| HR (bpm) | 279 ± 10 | 287 ± 10a | 304 ± 9 | 312 ± 7a |
| MT joints | ||||
| 1st application | ||||
| BP (mmHg) | 81 ± 5 | 86 ± 6a | 91 ± 3 | 97 ± 3a |
| HR (bpm) | 280 ± 8 | 287 ± 8a | 300 ± 8 | 304 ± 8a |
| 2nd application | ||||
| BP (mmHg) | 78 ± 5 | 81 ± 6a | 82 ± 5 | 84 ± 6 |
| HR (bpm) | 285 ± 10 | 287 ± 11a | 305 ± 8 | 305 ± 8 |
In the control (no drug) treatment group (n = 9), both mustard oil applications were in the absence of RX 821002, whilst the second mustard oil conditioning stimulus was performed after administration of RX 821002 (100–300 μg, intrathecally) in the RX 821002 treatment group (n = 10). Blood pressure and heart rate values are means ± SEM, and were taken 5 min and 10 min after mustard oil application, respectively.
BP, arterial blood pressure; HR, heart rate; MG, medial gastrocnemius; MT, metatarsophalangeal.
A significant difference from the pre‐mustard oil state (repeated‐measures anova, see main text for statistical details).