Table 4.

Sensitivity analyses on the association between dietary intakes of total flavonoids and lignans and pancreatic cancer risk

	Quintile of intake						Intake as continuous variable (log2)
	Q1	Q2	Q3	Q4	Q5	p for trend
Total Flavonoids
Non‐diabetics
Cases	168	147	138	155	165
HR (95% CI)	1.00	0.90 (0.71–1.13)	0.88 (0.69–1.13)	0.98 (0.77–1.26)	0.99 (0.76–1.29)	0.664	1.00 (0.92–1.08)
Microscopically confirmed
Cases	155	137	113	106	97
HR (95% CI)	1.00	1.01 (0.80–1.29)	0.99 (0.76–1.28)	1.03 (0.78–1.36)	1.15 (0.85–1.55)	0.321	1.02 (0.93–1.11)
> 2 years follow‐up
Cases	160	155	141	153	168
HR (95% CI)	1.00	1.01 (0.80–1.27)	1.00 (0.78–1.28)	1.09 (0.84–1.40)	1.12 (0.85–1.46)	0.343	1.03 (0.95–1.12)
Lignans
Non‐Diabetics
Cases	151	127	160	149	186
HR (95% CI)	1.00	0.85 (0.67–1.09)	1.04 (0.81–1.34)	0.86 (0.65–1.14)	0.93 (0.68–1.28)	0.830	0.99 (0.86–1.15)
Microscopically confirmed
Cases	138	104	120	110	136
HR (95% CI)	1.00	0.84 (0.64–1.09)	1.00 (0.76–1.32)	0.86 (0.63–1.18)	1.00 (0.70–1.42)	0.798	1.03 (0.87–1.21)
> 2 years follow‐up
Cases	151	126	159	146	195
HR (95% CI)	1.00	0.86 (0.67–1.10)	1.07 (0.83–1.37)	0.88 (0.66–1.16)	1.02 (0.74–1.39)	0.722	1.02 (0.88–1.18)

Multivariable HR—adjusted for total energy intake from fat and from non‐fat sources (continuous), body mass index in kg m⁻² (continuous), smoking status and intensity (never; current, 1–15 cigarettes per day, 16–25 cigarettes per day, 26+ cigarettes per day; former, quit ≤10 years, quit 11–20 years, quit 20+ years; current, pipe/cigar/occasional; current/former, missing; unknown), alcohol intake (non drinkers; drinkers of 0–6 g day⁻¹, >6–12 g day⁻¹, >12–24 g day⁻¹, >24–60 g day⁻¹; women drinkers of: >60 g day⁻¹; men drinkers of: >60–96 g day⁻¹, >96 g day⁻¹), diabetes status at recruitment (yes, diagnosis verified; yes, diagnosis self‐reported; not diabetic, missing status), and stratified by age (1‐year categories), sex, and centre.

PY: person‐years.