Figure 5.

(A) Pressure dependencies of the observed rate constants for the sequential hydride and proton transfers catalysed by POR at 25 °C. The rate of hydride transfer from NADPH (black) and proton transfer in H₂O (red) are indicated by filled symbols and the rate of deuteride transfer from pro‐S NADP ²H (black) and deuteron transfer in D₂O are indicated by open symbols. (B) The pressure dependence of the resulting KIEs. The data have been fitted to Eqn (2), with fitting parameters given in Table 2 and the KIEs on these parameters given in Table 3. The rate constants are listed in Table 1.