Figure 4.

Graphical representations of the DAGR entries. (a) Antibodies that target branched glycan structures (blue) are well represented in the DAGR. Antibodies targeting sialic acid charged epitopes are well represented; however sulfated or uronic acid containing glycan epitopes are conspicuously underrepresented (red). Common monosaccharides are present in a significant percentage of the epitopes targeted (green). (b) Cell/cell lysate (blue) and glycoprotein (red) immunizations are the preferred means of generating antibodies to glycans. Glycolipid (green), tissue preparation (purple), and synthetic antigen (orange) are other immunizations strategies. Antibodies to glycans have also been prepared as human isolates (pink) and from infected animals (black).