Table 3.
Change in protein intake and bodyweight per patient following long-term treatment with NCG (50 mg/kg/day) compared with pretreatment values.
| Patient | Diagnosis | Calendar month of treatment initiation | NCG treatment duration (months) | Pre-treatment protein (synthetic protein) intake (g/kg/day) | Increase in natural protein intake (%) | Weight gain (kg) |
|---|---|---|---|---|---|---|
| 1 | PA | September | 9 | 1.0 (0.5) | 50 | 1.5 |
| 2 | PA | November | 10 | 1.5 (0.4) | 20 | nc |
| 3 | PA | November | 10 | 1.2 (0.4) | 50 | 2.8 |
| 4 | PA | May | 12 | 1.5 (0.5) | 50 | 6.5 |
| 5 | MMA | October | 5 | 1.0 | 20 | 0.6 |
| 6 | MMA | March | 5 | 1.3 | – | nc |
| 7 | MMA | February | 4 | 1.0 | 20 | 0.6 |
| 8 | MMA | March | 3 | 1.1 | – | nc |
MMA, methylmalonic aciduria; NCG, N-carbamylglutamate; PA, propionic aciduria; nc, no change.