Fig. 1.

(A) Fluorescence micrographs of Jurkat cells treated with camptothecin (10 μM) for 3.5 h to induce apoptosis, then stained with PSVue-480 (green, 5 μM) and 7AAD (red, 500 ng/mL). (B) Flow cytometry histograms illustrating staining of Jurkat cells by PSVue-480 and 7AAD. A and B reprinted with permission from Ref. 89. © 2005 John Wiley and Sons. (C) X-ray and fluorescence overlay image of a rat prostate tumor model at 24 h postinjection of PSVue-794. Reprinted with permission from Ref. 92. © 2010 American Chemical Society. (D) Ex vivo epifluorescence image of a rat bearing two subcutaneous PAIII prostate tumors and dosed with PSVue-794. The right flank tumor received focal beam radiation therapy, and the left flank tumor was not treated. Reprinted with permission from Ref. 93. © 2011 Springer. (E) Whole body fluorescence image of a mouse with induced arthritis given a single dose of PSVue-794 48 hours prior to imaging. Arrows point to arthritic feet joints. Reprinted from open access Ref. 96. (F) Decay-corrected transaxial and coronal [¹⁸F]-ZnDPA PET images of a rat following acute myocardial infarction and 60 min after subsequent probe injection. The short red line indicates the location of the heart. Reprinted from open access Ref. 101.