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. Author manuscript; available in PMC: 2016 Jul 19.
Published in final edited form as: J Neurochem. 2010 May 13;114(3):820–831. doi: 10.1111/j.1471-4159.2010.06807.x

Figure 4.

Figure 4

Percent enrichment of glutamate, glutamine and aspartate isotopomers labeled from the metabolism of [2-13C]ALCAR in the TCA cycle in 21 day old rat brain. [4-13C]glutamate (GLU C4), [3-13C]glutamate (GLU C3), and [2-13C]glutamate (GLU C2) are formed from metabolism in the first, second and third turns of the TCA cycle respectively. [4-13C]glutamine (GLN C4), [3-13C]glutamine (GLN C3), and [2-13C]glutamate (GLU C2) are formed from the corresponding glutamate isotopomers. [2-13C]ALCAR was injected intraperitoneally and rats were euthanized at 15, 60 or 120 min after injection. Spectra were obtained on PCA extracts of brain as described in methods. Values are mean ± S.E. of data from n = 5 brains at 15 min, n=6 at 60min, and n = 8 at 120 min. Data were analyzed using one-way ANOVA and Tukey’s post hoc test. Asterisks indicate significant difference between time points, *p<0.05, **p<0.01.