Figure 7.

Changes in cerebellar cortical network caused by the lack of β₄ in adult lethargic mice. In the absence of β₄ the input from PFs is reduced, whereas the input from CFs is spared. Thus, the PC inputs are unbalanced. The size of PCs (dendritic branching) and the width of the granular cell layer are reduced. The firing frequency of PCs and thus cerebellar output is reduced. All these deficits affect only adult and not juvenile lethargic mice, consistent with a developmental retardation of cerebellar cortical networks in lethargic mice.