Table 1. Bladder blood flow, voiding patterns and conscious cystometric parameters after 8- and 16-week bladder ischemia.
| Group | BBF | MF | VV (mL) | BP (cmH2O) | TP (cmH2O) | MP (cmH2O) | RV (mL) | BC (mL) |
|---|---|---|---|---|---|---|---|---|
| 8-Week sham | 10.8±1.3 | 13.3±1.2 | 1.28±0.12 | 9.9±1.0 | 20.5±2.1 | 50.5±1.9 | 0.11±0.01 | 1.68±0.09 |
| 8-Week ischemia | 5.3±0.8* | 18.2±1.3* | 0.90±0.09* | 12.3±1.5 | 22.3±1.9 | 52.3±2.4 | 0.12±0.01 | 1.22±0.14* |
| 16-Week sham | 8.9±1.2 | 14.1±1.1 | 1.33±0.16 | 12.2±1.2 | 17.3±2.2 | 49.6±2.6 | 0.15±0.03 | 1.80±0.17 |
| 16-Week ischemia | 3.4±0.5* | 9.3±1.2* | 0.95±0.11 | 10.7±1.1 | 15.7±2.3 | 41.5±1.7* | 0.29±0.03* | 2.55±0.23* |
Values are presented as mean±standard error.
Hemodynamic measurements, metabolic cage data and conscious cystometric findings in 8- and 16-week bladder ischemia versus corresponding sham groups. At 8-week ischemia, bladder blood flow (BBF, mL/min/100-g tissue) was lower (p=0.003), micturition frequency (MF) per 24 hours was greater (p=0.043), and voided volume (VV) was smaller (p=0.035). BBF and MF decreased (p=0.002 and p=0.021, respectively) at 16-week ischemia. VV at 16-week ischemia was not significantly different versus 16-week sham (p=0.076). There was no significant difference in baseline bladder pressure (BP) and threshold pressure (TP) among the animals. Micturition pressure (MP) decreased after 16-week ischemia (p=0.025). Postvoid residual volume (RV) and bladder capacity (BC) increased at 16-week ischemia (p=0.008 and p=0.026, respectively).