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Survival of RML‐ and ME7‐ inoculated MloxP and NFH‐Cre/MloxP mice. Mice were inoculated with RML or ME7 prions at 1 week of age. MloxP mice (blue line) became terminally ill at approximately 12 wpi (RML, A) or at approximately 17 wpi (ME7, B). In contrast to previous experiments, recombined NFH‐Cre/MloxP mice (red) ultimately developed prion disease at approximately 35 weeks (A) or approximately 29 weeks (B) but both showed significant delay of their incubation time (P < 0.001).
