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. 2015 Apr 23;41(5):613–630. doi: 10.1111/nan.12189

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© 2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cre‐mediated recombination in the locus coeruleus (LC), the nucleus of the solitary tract (NTS) and the pre‐Bötzinger complex (PBC) of NFH‐Cre/ROSA26 mice. A,B schematic representations adapted from the Paxinos Mouse Atlas, coordinates −5.34 mm (A) and −6.84 mm (B) from Bregma. A1,B1,B2 β‐galactosidase immunoreactivity in the LC (A1), the NTS (B1) and the PBC (B2) of NFH‐Cre/ROSA26 mice. Immunostaining for β‐galactosidase is characterized by a diffuse accumulation in the cytoplasm as well as few small intracellular cytoplasmic inclusions. In the LC, ca. half of the cells express β‐galactosidase, indicating partial recombination (A1). In the nucleus of the solitary tract (B1) and in the pre‐Bötzinger complex (B2), recombination was less widespread. Scale bar = 80 μm.