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The progeny of SOX2+ pituitary stem cells give rise to the cell clusters but are not the cell‐of‐origin of mouse ACP. Double immunofluorescence staining reveals the presence of a β‐catenin‐accumulating tumour (asterisk) that is YFP −ve. Note that YFP −ve tumour is adjacent to YFP +ve cell clusters showing nucleo‐cytoplasmic β‐catenin accumulation (arrowheads). Reproduced with permission from Elsevier (Andoniadou et al., Cell Stem Cell 2013, vol. 13, issue 4, pp 433–445).
