Table 5.
Inhibitory effect of FXC on inflammatory mediators in exudate of air pouch
| Estimated values/(Percent inhibition) | |||||
|---|---|---|---|---|---|
| Dose/route | TNF-α (pg/ml) | IL-6 (pg/ml) | NO (μM/ml) | PGE2 (pmole/ml) | |
| Saline | 2 ml i.p. | 5.50 ± 1.04d | 27.66 ± 5.00c | 0.443 ± 0.058d | 1301.8 ± 90.87b |
| Carrageenan | 10 ml/kg p.o. | 964.50 ± 95.525a | 6291.3 ± 562.77a | 0.784 ± 0.105a | 1525.7 ± 75.76a |
| Diclofenac sodium | 10 mg/kg p.o. | 418.50 ± 57.83c | 4544.8 ± 235.87b | 0.362 ± 0.043c | 1339.7 ± 25.17b |
| 56.44 ± 6.01 | 34.03 ± 3.42 | 56.11 ± 4.99 | 7.69 ± 1.73 | ||
| FXC | 100 mg/kg p.o. | 592.33 ± 45.31b | 5146.2 ± 257.58b | 0.605 ± 0.060b | 1404.7 ± 21.37ab |
| 38.35 ± 4.71 | 25.30 ± 3.73 | 26.71 ± 7.33 | 3.21 ± 1.47 | ||
| FXC | 200 mg/kg p.o. | 505.67 ± 36.037bc | 4398.2 ± 159.46b | 0.408 ± 0.049bc | 1309.8 ± 30.46b |
| 47.37 ± 3.75 | 36.16 ± 2.31 | 50.52 ± 5.96 | 9.74 ± 2.09 | ||
FXC F. xanthoxyloides chloroform fraction, tumor necrosis factor- α (TNF-α), interleukin-6 (IL-6), nitric oxide (NO), prostaglandin E2 (PGE2). Count of cells is presented as mean ± SD (n = 6). One way analysis of variance for inflammatory mediators was followed by multiple comparisons by Tukeys’ HSD test. Superscript alphabets indicate significance among treatments (P <0.001) on not sharing common letter