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. 2016 Jul 19;9:42. doi: 10.1186/s13048-016-0253-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Tumor-bearing nude mice model experiment. a growth curve of tumor volume. The tumor growth speed in the UHRF1 Silence group was much slower than that in the Blank group and NC group; b tumor weight. The tumor weight in the UHRF1 Silence group was much lower than that in the Blank group and the NC group; c immunohistochemical staining of tumor sections; d the number of PCNA-positive cells. The number of UHRF1-positive and PCNA-positive cells in the UHRF1 Silence group was much smaller than that in the Blank group and NC group. *, P < 0.05 compared with the NC group; #, P < 0.05 compared with the NC group; UHRF1, ubiquitin-like, containing plant homeodomain (PHD) and really interesting new gene (RING) finger domains 1; NC, negative control; PCNA, proliferating cell nuclear antigen