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. 2016 Jul 18;17:50. doi: 10.1186/s12868-016-0288-1

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effects of PICALM siRNA targeting isoforms 1 and 2 of PICALM on APP processing. Levels of a APP and b βCTF in H4 cells, as detected by ELISA following incubation with media, or siRNA targeting either total PICALM (sequence A), PICALM isoform 1, PICALM isoform 2 or GFP for 48 h. Data are expressed as % of media control and are mean ± SEM, *p < 0.01, ***p < 0.001 significantly different to GFP siRNA with a one-way analysis of variance and Dunnett’s multiple comparison test, n = 5 (a) and, n = 4–5 (b)