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. 2016 Jul 18;17:50. doi: 10.1186/s12868-016-0288-1

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Differential effects of clathrin siRNA on isoforms 1 and 2 of PICALM and APP processing. H4 cells were incubated with media, control siRNA (GFP siRNA) or siRNA targeting clathrin heavy chain (Clathrin siRNA) for 48 h. a Representative immunoblot of isoforms 1 and 2 of PICALM and b following densitometric analysis of isoform 1 and c isoform 2. Data are presented as a percentage of the untreated media control after normalisation to house-keeping protein levels and are mean ± SEM. Levels of d APP, e βCTF and f BACE1 as detected by ELISA. Data are expressed as % of media control and are mean ± SEM. N = 3 for all, *p < 0.05 significantly different to GFP siRNA with an unpaired Student’s t test