Table 1.
Effect of tomato and broccoli extract on serum insulin, glucose, on calculated HOMA- IR and R-QUICKI in HFD induced obesity in rats
| Groups | Serum insulin (uIU/ml) | Serum glucose (mg/dl) | HOMA-IR | R-QUICKI |
|---|---|---|---|---|
| Control | 2.52 ± 0.28 | 67.8 ± 3.23 | 0.43 ± 0.06 | 0.455 ± 0.01 |
| HFD | 44.1 ± 2.14* | 169 ± 1.38* | 18.5 ± 0.96* | 0.25 ± 0.004* |
| SD | 30.9 ± 1.28*,** | 156 ± 1.86*,** | 11.9 ± 0.41*,** | 0.27 ± 0.004*,** |
| T 200 | 12.1 ± 0.75*,**,*** | 138 ± 3.82*,**,*** | 4.15 ± 0.34*,**,*** | 0.31 ± 0.008*,**,*** |
| T 400 | 6.72 ± 0.36*,**,*** | 99.3 ± 4.0*,**,*** | 1.66 ± 0.15*,**,*** | 0.35 ± 0.01*,**,*** |
| B 200 | 19 ± 0.71*,**,*** | 136 ± 3.0*,**,*** | 6.39 ± 0.22*,**,*** | 0.29 ± 0.004*,**,*** |
| B 400 | 9.38 ± 0.47*,**,***,**** | 115 ± 2.96*,**,***,**** | 2.67 ± 0.18*,**,***,**** | 0.33 ± 0.008*,**,***,**** |
| CX | 9.48 ± 0.53*,**,***,**** | 108 ± 2.79*,**,*** | 2.54 ± 0.2*,**,***,**** | 0.33 ± 0.01*,**,***,**** |
Tomato and broccoli extracts treatment at different doses significantly reduced serum levels of insulin and glucose in HFD rats. These extracts also significantly reduced HOMA-IR increased R- QUICKI. C = control; HFD = high fat diet; SD = stop diet; T 200 = tomato extract 200 mg/kg; T 400 = tomato 400 mg/kg; B 200 = broccoli 200 mg/kg; B 400 = broccoli 400 mg/kg; CX = Chromax. HOMA-IR = Homeostasis model assessment index for insulin resistance; R-QUICKI = revised quantitative insulin sensitivity check index. Results were expressed as mean ± SEM and analyzed using one-way ANOVA followed by Bonferroni’s post hoc test. *Significant from control at P < 0.0001, **Significant from HFD at P < 0.0001, ***Significant from SD at P < 0.0001, ****Significant from T 400 at P < 0.005. Results were expressed as mean ± SEM and analyzed using one-way ANOVA followed by Bonferroni’s post hoc test