Table 7.
Second-Trimester Thyroid Hypofunction and Pregnancy Outcomes
| Outcome | Unadjusted
|
Adjusted*
|
||||
|---|---|---|---|---|---|---|
| Subclinical Hypothyroid (%) | Euthyroid (%) | Odds Ratio | 95% Confidence Interval | Odds Ratio | 95% Confidence Interval | |
| Miscarriage | 0.9 | 0.6 | 1.34 | 0.33–5.49 | 1.29 | 0.31–5.36 |
| Gestational hypertension | 4.6 | 5.4 | 0.86 | 0.47–1.59 | 0.99 | 0.53–1.84 |
| Preeclampsia | 0.8 | 1.0 | 0.87 | 0.21–3.55 | 1.08 | 0.26–4.43 |
| Gestational diabetes | 1.7 | 3.0 | 0.56 | 0.21–1.53 | 0.63 | 0.23–1.73 |
| Placenta previa | 0.8 | 0.4 | 2.03 | 0.49–8.44 | 1.96 | 0.47–8.18 |
| Placental abruption | 0.8 | 0.9 | 0.93 | 0.23–3.80 | 0.93 | 0.23–3.81 |
| Preterm labor | 3.8 | 6.2 | 0.60 | 0.31–1.17 | 0.61 | 0.31–1.20 |
| Preterm PROM | 1.7 | 1.4 | 1.22 | 0.45–3.33 | 1.33 | 0.49–3.64 |
| Delivery less than 37 wk | 5.1 | 7.3 | 0.69 | 0.38–1.24 | 0.71 | 0.40–1.28 |
| Birth weight less than 2,500 g | 2.5 | 4.2 | 0.59 | 0.26–1.34 | 0.61 | 0.27–1.40 |
| Birth weight more than 4,000 g | 7.6 | 8.9 | 0.85 | 0.52–1.38 | 0.93 | 0.57–1.51 |
| Perinatal mortality | 0.0 | 0.3 | – | – | – | – |
PROM, premature rupture of membranes.
*
Adjusted for maternal age, prior pregnancy, body mass index, and study site.