Figure 4.
DiI-retaining cells demonstrate significant resistance to irradiation and temozolomide treatment. Proliferative potentials of the DiI-retaining and DiI-negative cells in the NCH421k, NCH441 and NCH644 glioblastoma sphere lines prior to and following (A) irradiation or (B) temozolomide treatment. The data are presented as the mean ± standard deviation from three independent experiments. *P<0.05, DiI-retaining cells vs. DiI-negative cells with irradiation/temozolomide in the respective cell lines, or DiI-negative cells prior to irradiation/temozolomide vs. DiI-negative cells following irradiation/temozolomide. OD, optical density.