Figure 8.

Strong impact of polar secretion and lateral diffusion parameters on polarity establishment and maintenance in the polar secretion model. (a) The polarity index profile dramatically changed depending on the secretion intensity. The model depicted by asterisk includes the experimentally obtained secretion parameter (based on the calculated half-recovery time of GFP-ABCG37 kSPEX ~0.005 min⁻¹). Other models represent cell polarity variants dependent on secretion rate, from very high (red, kSPEX=0.5 min⁻¹) to very low (light green, kSPEX=0.00005 min⁻¹), accordingly. (b) Impact of lateral diffusion on the protein polarization dynamics. The model depicted by asterisks includes representative lateral diffusion parameters obtained experimentally efficiency for GFP-ABCG37 (0.145 μm² s⁻¹±0.0597). Other models represent cell polarity variants dependent on lateral diffusion, from very slow (red, Dm=0.00001 μm² s⁻¹) to very fast (light green, Dm=1 μm² s⁻¹), accordingly. Protein levels are represented by color coding scheme, from low (0.0001) to high (1; log scale).