Table I.
Association of TRPM8 expression with clinicopathological features of osteosarcoma.
| TRPM8 | ||||
|---|---|---|---|---|
| Features | Cases, n | Positive, n (%) | Negative, n (%) | P-valuea |
| Age at diagnosis | 0.481 | |||
| <18 years | 47 | 30 (63.8) | 17 (36.2) | |
| ≥18 years | 51 | 29 (56.9) | 22 (43.1) | |
| Gender | 0.905 | |||
| Female | 42 | 25 (59.5) | 17 (40.5) | |
| Male | 56 | 34 (60.7) | 22 (39.3) | |
| Histological subtype | 0.207 | |||
| Osteoblastic | 44 | 22 (50.0) | 22 (50.0) | |
| Chondroblastic | 20 | 15 (75.0) | 5 (25.0) | |
| Fibroblastic | 14 | 9 (64.3) | 5 (35.7) | |
| Mixed | 20 | 14 (70.0) | 6 (30.0) | |
| Clinical stage | 0.007 | |||
| I+IIA | 62 | 31 (50.0) | 31 (50.0) | |
| IIB/III | 36 | 28 (77.8) | 8 (22.2) | |
| Distant metastasis | 0.030 | |||
| Absent | 60 | 31 (51.7) | 29 (48.3) | |
| Present | 38 | 28 (73.7) | 10 (26.3) | |
| Tumor size | 0.429 | |||
| <5 cm | 53 | 30 (56.6) | 23 (43.4) | |
| ≥5 cm | 45 | 29 (64.4) | 16 (35.6) | |
| Anatomic location | 0.369 | |||
| Tibia/femur | 60 | 34 (56.7) | 26 (43.3) | |
| Elsewhere | 38 | 25 (65.8) | 13 (34.2) | |
a
P-value obtained from Pearson χ2 test or Fisher's exact test. TRPM8, transient receptor potential melastatin member 8.