Table II.
Cox regression analysis of clinicopathological data associated with OS and DFS in osteosarcoma.
| OS | DFS | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| Factor | RR | Pa | RR | Pb | RR | Pa | RR | Pb |
| Age, years (≥18/<18) | 1.309 | 0.289 | 1.230 | 0.434 | 1.263 | 0.322 | 1.164 | 0.536 |
| Gender (male/female) | 0.904 | 0.694 | – | – | 1.109 | 0.666 | – | – |
| Tumor size, cm (≥5/<5) | 1.711 | 0.036 | 2.018 | 0.011 | 1.617 | 0.042 | 1.723 | 0.030 |
| Histological subtype (mixed/fibroblastic/chondroblastic/osteoblastic) | 0.978 | 0.827 | – | – | 1.017 | 0.855 | – | – |
| Clinical stage (IIB/III/I+IIA) | 2.065 | 0.005 | 0.369 | 0.251 | 4.294 | 0.034 | 0.308 | 0.166 |
| Distant metastasis (present/absent) | 2.364 | 0.001 | 7.196 | 0.024 | 1.885 | 0.009 | 6.579 | 0.027 |
| Anatomic location (tibia/femur/elsewhere) | 1.709 | 0.036 | 1.408 | 0.288 | 2.017 | 0.003 | 1.752 | 0.028 |
| TRPM8 (positive/negative) | 2.045 | 0.011 | 1.855 | 0.040 | 1.910 | 0.011 | 1.700 | 0.051 |
a
P-value and RR were assessed using univariate Cox regression analysis
b
P-value and RR were assessed using multivariate Cox regression analysis. OS, overall survival; DFS, disease-free survival; RR, relative risk.