Figure 4.

Anti-tumor effect of RPR extract in a mouse orthotopic bladder tumor model. (A) Mouse body weight and drug schedule. MB49 cells stably transformed with the luciferase gene were implanted in the mice on day 1. Following tumor implantation, RPR extract was applied intravesically nine times. Mouse body weights were recorded prior to every intravesical application. (B) Following euthanization of the mice, the bladders were collected. Intravesical application of RPR extract decreased the bladder tumor growth of the RPR-treated mice. Bladder volume (mm³) = (length × wide²) / 2. Data are represented as the mean ± standard error of the mean. ***P=0.001.