Figure 2.

Incorporation of the transgene in wild‐type mice improves the myofiber function. (A) Typical muscle cross‐sections from the atrium or tibialis anterior muscles from wild‐type animals. The tibialis anterior muscles were injected with ∼1 × 10¹⁰ vector genomes of rAAV6 containing either the MYL4 gene (referred to as MYL4) or a vector lacking a functional gene (referred to as MCS). These cross‐sections were stained for MyLC_1a/emb. The scale bar represents 50μm. (B–E) B, D, and E are graphs depicting the myofiber mechanics, whereas C summarizes the myosin to actin content ratio in these myofibers. Values in the graphs are mean ± standard error of the mean. *Statistically significant at p < 0.05. [Color figure can be viewed in the online issue, which is available at www.annalsofneurology.org.]