Figure 7.

Areas of low shear stress are greater in sickle cell anemia arteries. Low WSS (±5 dynes/cm²) during diastole were calculated from the velocity profiles of the non-sickle and sickle subjects. The locations of these low WSS (circles) are magnified in the images to the right for easier viewing. In the non-sickle subject (P1), two spots of low stress areas of low shear stress occur at the apex of the internal carotid bifurcation (1) (a). The sickle subject with no history of stroke (P2) has regions of low WSS occur along the inner curvature both bifurcations in the ACA (1), MCA (2), M2-B (3), and M2-A (4) (b). The second subject (P3) has multiple regions of low WSS. Two occur in the ICA, first at the stenosis (1) and then preceding the ICA bifurcation (2). Low shear areas also occur along the length of the MCA, one following the ICA bifurcation (3), and the other at the apex of the MCA bifurcation (4) (c)