Table 4.

Primary hypotheses of AWAKEN.

Hypothesis #1: Neonatal AKI is associated with short-term risk, even when adjusted for gestational age at birth, birthweight, 5 min Apgar score, congenital renal anomalies, and severity of illness score	Survival of infants to discharge or 120 days of age (or to 36 weeks’ postmenstrual age in infants born preterm) is less likely in babies with the diagnosis of AKI
	Length of stay is longer in infants with neonatal AKI
	Discharge serum creatinine is higher in infants with neonatal AKI
Hypothesis #2: Maternal and infant risk factors predict AKI
Hypothesis #3: Fluid balance during the first week after birth is associated with short-term risk	Survival of infants to discharge or 120 days of age (or to 36 weeks’ postmenstrual age in infants born preterm) is less likely in babies with excessive fluid intake compared to output
	Changes in weight are a better indication of fluid balance, especially in the preterm population, than difference between fluid intake and measured output
	Length of stay is longer in infants with neonatal AKI
	Pulmonary outcomes, as measured by time to extubation and development of bronchopulmonary dysplasia, are worse in infants with evidence of fluid overload
	Discharge serum creatinine is higher in infants with fluid overload