Table 2.

Adjusted HRs and 95% CIs for objectively measured incident hypertension by FGF23 category, ARIC, 1990–98 (total n=7,948; total developing hypertension = 2,152).

Serum FGF-23 (pg/mL) Categories
Category	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Decile 9	Decile 10
Median	25.9	34.7	40.7	47.8	55.9	73.2
Range	2.9 – 31.3	31.4 – 37.8	37.9 – 43.8	43.9 – 52.4	52.5 – 60.5	60.6 – 181.8
N total	1,589	1,590	1,590	1,590	795	794
N events	405	424	426	416	215	266
Model
Model 1	1	0.97 (0.88, 1.06)	0.97 (0.89, 1.06)	0.96 (0.87, 1.05)	0.95 (0.85, 1.07)	1.27 (1.14, 1.42)
Model 2	1	0.97 (0.89, 1.07)	0.97 (0.89, 1.06)	0.95 (0.87, 1.04)	0.93 (0.83, 1.05)	1.24 (1.11, 1.39)
Model 3	1	0.98 (0.90, 1.07)	0.98 (0.89, 1.07)	0.96 (0.87, 1.05)	0.94 (0.83, 1.05)	1.21 (1.08, 1.35)

Model 1: Adjusted for age, race, sex, ARIC field center, and educational attainment.

Model 2: Adjusted for Model 1 + cigarette smoking, alcohol intake, physical activity, body mass index, and serum phosphorus.

Model 3: Adjusted for Model 2 + eGFR category.