Table 3.
Adjusted HRs and 95% CIs for self-reported incident hypertension by FGF23 category, ARIC, 1990–2012 (total n=7,644; total developing hypertension = 4,128).
| Serum FGF-23 (pg/mL) Categories | ||||||
|---|---|---|---|---|---|---|
| Category | Quintile 1 | Quintile 2 | Quintile 3 | Quintile 4 | Decile 9 | Decile 10 |
| Median | 25.1 | 35.3 | 42.9 | 47.9 | 53.8 | 74.1 |
| Range | 2.8 – 31.1 | 31.2 – 39.1 | 39.2 – 44.8 | 44.9 – 53.9 | 54.0 – 60.6 | 60.7 – 181.9 |
| N total | 1,529 | 1,529 | 1,529 | 1,529 | 764 | 764 |
| N events | 803 | 831 | 828 | 839 | 399 | 428 |
|
| ||||||
| Model | ||||||
| Model 1 | 1 | 1.10 (1.00, 1.19) | 1.11 (0.98, 1.19) | 1.16 (1.07, 1.27) | 1.21 (1.09, 1.34) | 1.33 (1.20, 1.48) |
| Model 2 | 1 | 1.09 (0.99, 1.16) | 1.09 (0.99, 1.16) | 1.11 (1.02, 1.21) | 1.14 (1.03, 1.27) | 1.23 (1.11, 1.37) |
| Model 3 | 1 | 1.09 (1.00, 1.16) | 1.09 (0.99, 1.16) | 1.10 (1.02, 1.20) | 1.13 (1.03, 1.26) | 1.21 (1.10, 1.37) |
Model 1: Adjusted for age, race, sex, ARIC field center, and educational attainment.
Model 2: Adjusted for Model 1 + cigarette smoking, alcohol intake, physical activity, body mass index, and serum phosphorus.
Model 3: Adjusted for Model 2 + eGFR category.