Table 4.

Adjusted HRs and 95% CIs for incident hypertension by FGF23 category, ARIC, sensitivity analyses for individuals without coronary heart disease (CHD)^* and pre-hypertension.^†

Model	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Decile 9	Decile 10
Main Results
Model 1	1	0.97 (0.88, 1.06)	0.97 (0.89, 1.06)	0.96 (0.87, 1.05)	0.95 (0.85, 1.07)	1.27 (1.14, 1.42)
Model 2	1	0.97 (0.89, 1.07)	0.97 (0.89, 1.06)	0.95 (0.87, 1.04)	0.93 (0.83, 1.05)	1.24 (1.11, 1.39)
Model 3	1	0.98 (0.90, 1.07)	0.98 (0.89, 1.07)	0.96 (0.87, 1.05)	0.94 (0.83, 1.05)	1.21 (1.08, 1.35)
Sensitivity Analysis: Individuals without CHD*
Model 1	1	1.08 (0.94, 1.24)	1.08 (0.94, 1.24)	1.04 (0.91, 1.20)	1.02 (0.86, 1.21)	1.43 (1.22, 1.68)
Model 2	1	1.04 (0.90, 1.19)	1.02 (0.89, 1.18)	0.99 (0.86, 1.14)	0.95 (0.80, 1.13)	1.33 (1.13, 1.57)
Model 3	1	1.04 (0.91, 1.20)	1.03 (0.89, 1.18)	1.00 (0.86, 1.15)	0.96 (0.80, 1.14)	1.30 (1.11, 1.54)
Sensitivity Analysis: Individuals without pre-hypertension†
Model 1	1	1.23 (0.96, 1.56)	1.13 (0.89, 1.44)	1.11 (0.87, 1.42)	1.54 (1.18. 2.02)	1.58 (1.20, 2.10)
Model 2	1	1.19 (0.93, 1.51)	1.08 (0.84, 1.38)	1.07 (0.83, 1.37)	1.49 (1.14, 1.95)	1.51 (1.13, 2.00)
Model 3	1	1.21 (0.95, 1.54)	1.09 (0.85, 1.40)	1.07 (0.83, 1.38)	1.49 (1.14, 1.96)	1.42 (1.06, 1.90)

^*CHD defined as self-reported physician diagnosis of myocardial infarction (MI) or coronary revascularization (coronary artery bypass surgery or angioplasty), prevalent MI diagnosed from ECG at visit 1, or an incident adjudicated CHD event between ARIC visits 1 and 2.

^†Pre-hypertension defined as systolic blood pressure 120–139 mm Hg or diastolic blood pressure of 80–89 mm Hg.

Model 1: Adjusted for age, race, sex, ARIC field center, and educational attainment.

Model 2: Adjusted for Model 1 + cigarette smoking, alcohol intake, physical activity, body mass index, and serum phosphorus.

Model 3: Adjusted for Model 2 + eGFR category.