The density of the healthy, catabolic and EPOR-active chondrocytes (C(r, t), ST(r, t), SA(r, t)) at t = 2, 4, 6, 8, 10 days with ε = 0.8 and σP = 4.2 · 10−5 (heavy strain with low EPO production). With high strain we have cell death further from the strike zone and our penumbra (the region dominated by ST and SA) has widened compared to the low and medium strain cases, resulting in a much larger lesion.