Table III.
Genotype and allele frequency distributions of osteoprotegerin genetic polymorphisms and their associations with intervertebral disc degeneration risk.
| Locus | Genotype/Allele | Control Group [n (%)] | Case group [n (%)] | P1 | OR (95% CI) | P2 |
|---|---|---|---|---|---|---|
| rs2073617 | TT | 112 (56.0) | 84 (41.8) | 0.018 | Ref. | |
| TC | 55 (32.8) | 70 (35.2) | 1.69 (1.07–2.67) | 0.021 | ||
| CC | 33 (11.2) | 46 (23.0) | 1.19 (1.10–3.16) | 0.020 | ||
| TC+CC | 88 (46.0) | 116 (58.2) | 1.76 (1.18–2.61) | 0.005 | ||
| T | 290 (72.4) | 238 (59.4) | <0.001 | Ref. | ||
| C | 110 (27.6) | 162 (40.6) | 1.79 (1.33–2.41) | <0.001 | ||
| rs2073618 | GG | 107 (53.5) | 111 (55.2) | 0.890 | Ref. | |
| CG | 77 (38.5) | 75 (37.8) | 0.94 (0.62–1.42) | 0.765 | ||
| CC | 16 (8.0) | 14 (7.0) | 0.84 (0.39–1.81) | 0.662 | ||
| CC+CG | 93 (46.5) | 89 (44.8) | 1.04 (0.70–1.53) | 0.845 | ||
| G | 291 (72.8) | 304 (74.1) | 0.292 | Ref. | ||
| C | 109 (27.3) | 96 (25.9) | 1.07 (0.78–1.47) | 0.682 | ||
| rs3102735 | AA | 116 (58.4) | 113 (56.6) | 0.945 | Ref. | |
| AG | 54 (26.4) | 55 (27.0) | 1.05 (0.87–1.17) | 0.848 | ||
| GG | 30 (15.2) | 32 (16.4) | 1.10 (0.62–1.92) | 0.781 | ||
| AG+GG | 84 (41.6) | 87 (43.4) | 1.06 (0.71–1.58) | 0.761 | ||
| A | 287 (71.6) | 280 (70.1) | 0.586 | Ref. | ||
| G | 113 (28.4) | 120 (29.9) | 1.09 (0.80–1.47) | 0.586 |
P1, comparison of genotypes and allele frequencies between the case and control groups; P2, comparison with the control group in the risk assessment. OR, odds-ratio; CI, confidence interval; P, P-value.