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. 2016 Jun 13;12(2):837–846. doi: 10.3892/ol.2016.4704

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — EZH2 overexpression promotes the in vivo tumorigenicity of AMC-HN-8 cells. (A) AMC-HN-8 cells and EZH2-OE cells were injected into NOD mice, and the resultant tumors were evaluated 20 days later. (B) Representative tumor masses that were removed from the sacrificed NOD mice. (C) Weights of the tumors derived from the AMC-HN-8 cells and EZH2-OE cells. *P<0.05. (D) Tumor tissues were stained using hematoxylin-eosin and observed under a fluorescence microscope. The tumors exhibited the characteristics of squamous cell cancers. AMC-HN-8 group at (a) magnification, ×100 and (b) magnification, ×200. EZH2-OE group at (c) magnification, ×100 and (d) magnification, ×200. EZH2, enhancer of zeste 2 polycomb repressive complex 2 subunit; EZH2-OE, EZH2-overexpressing; NOD, non-obese diabetic.