Table 1.
Characteristics: weight, BSA, CQ real-dose, CQ theoretical dose, and blood concentrations of CQ on day 7 of follow-up in each group
| Age group (years) | Number records | Weight (kg) | BSAa (m2) | CQ real doseb (mg) | CQ theoretical dosec (m2) | CQD7d (ng/ml) |
|---|---|---|---|---|---|---|
| 5–9 | 10 | 21.15 (SD 5.02) | 0.83 (SD 0.13) | 536.50 (SD 120.69) | 717.71 (SD 112.48) | 235.47 (SD 69.92) |
| 10–14 | 14 | 42.92 (SD 9.02) | 1.33 (SD 0.18) | 1085.50 (SD 231.58) | 1156.80 (SD 156.32) | 308.20 (SD 89.69) |
| 15–24 | 36 | 61.42 (SD 9.48) | 1.68 (SD 0.15) | 1542.81 (SD 239.85) | 1458.84 (SD 133.87) | 342.72 (SD 165.28) |
| 25–34 | 14 | 62.12 (SD 12.60) | 1.68 (SD 0.20) | 1562.29 (SD 322.06) | 1460.28 (SD 174.16) | 455.35 (SD 137.86) |
| 35–44 | 11 | 71.32 (SD 12.94) | 1.83 (SD 0.19) | 1782.82 (SD 323.69) | 1589.72 (SD 162.42) | 395.02 (SD 199.02) |
| 45–54 | 6 | 64.67 (SD 8.74) | 1.74 (SD 0.13) | 1604.08 (SD 238.12) | 1510.06 (SD 115.54) | 384.57 (SD 51.47) |
| 55–65 | 4 | 69.75 (SD 13.60) | 1.80 (SD 0.21) | 1745.00 (SD 342.08) | 1564.96 (SD 183.79) | 391.20 (SD 94.90) |
CQ chloroquine, DCQ desethylchloroquine, SD standard deviation
aBSA in m2 = body surface area calculated using the Boyd formula
BSA (m2) = 0.0003207 × height (cm) 0.3 × weight (g) 0.7285 – [0.0188 × log (weight)]
bCQ real dose: CQ taken in mg/kg/weight
cCQ theoretical dose: CQ dose according to: (BSA/1.73)*1500 (adult dose)
dCQD7: CQ + DCQ on day 7 of follow-up