Table I.
Inhibition rate of 4 synthetic analogs of Glu-urea-R to prostate-specific membrane antigen.
| Inhibition, % | |||||
|---|---|---|---|---|---|
| log concentration, µM | Glu-Urea-Lys | Glu-Urea-Orn | Glu-Urea-Asn | Glu-Urea-Gln | 2-PMPA |
| 1 | 85.488469 | 71.517575 | 87.521311 | 87.316559 | 93.611272 |
| 0.3010 | 77.366075 | 81.439916 | 83.885526 | 89.210723 | 92.531223 |
| −0.3979 | 52.428683 | 57.259946 | 65.909721 | 82.020320 | 92.567931 |
| −1.0969 | 8.406071 | 19.438644 | 31.258820 | 58.004315 | 86.281376 |
| −1.7959 | 0.731113 | 7.434516 | 9.939268 | 24.502802 | 61.777146 |
| −2.4949 | −4.746629 | 2.362200 | 1.307847 | 4.772733 | 20.431408 |
| −3.1938 | −4.261259 | 1.230759 | 2.202313 | 1.983285 | 1.781796 |
| −3.8928 | −5.881333 | −3.697986 | 4.722972 | 1.554202 | 0.792702 |
Glu-urea, glutamic urea small molecule; Orn, Asn, asparagine; Gln, glutamine; Lys, lysine; 2-PMPA, 2-phosphonomethyl pentanedioic acid.