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Correlation of relative MMP serum expression (serum/control serum) and overall survival in univariate analysis. An expression ratio serum/control serum ≥2 was defined as increased expression. Overall survival was significantly impaired in patients with increased relative serum expression of (a) MMP7 (HR: 2.8 [95 % CI: 1.1–6.8], p = 0.02) (b) MMP10 (HR: 2.6 [95 % CI: 1.2–5.9], p = 0.015) and (c) MMP12 (HR: 2.9 [95 % CI: 1.1–7.8], p = 0.025). CI = Confidence interval, HR = Hazard ratio
