Table 3.
Multivariate analysis (Cox proportional hazards regression model) of prognostic parameters for overall survival in colon cancer. A MMP10 relative serum expressional ratio ≥2 is an independent prognostic marker in colon cancer patients
| Patient characteristics | Hazard ratio | 95 % Confidence interval of relative risk | p-value |
|---|---|---|---|
| Median age | 1.372 | 0.477–3.943 | 0.557 |
| Gender | 1.275 | 0.364–4.464 | 0.704 |
| UICC stage | 1.081 | 0.232–5.027 | 0.921 |
| T-stage | 0.775 | 0.277–2.174 | 0.629 |
| N-stage | 1.68 | 0.518–5.447 | 0.387 |
| M-stage | 1.813 | 0.255–12.912 | 0.562 |
| R-stage | 0.673 | 0.112–4.033 | 0.665 |
| Grading | 1.127 | 0.405–3.137 | 0.820 |
| Adjuvant chemotherapy | 1.251 | 0.236–6.636 | 0.792 |
| Anastomotic leakage | 0.518 | 0.09–2.992 | 0.462 |
| MMP7 relative serum expression ≥2 | 0.901 | 0.170–4.788 | 0.903 |
| MMP10 relative serum expression ≥2 | 3.866 | 1.069–13.976 | 0.039 |
| MMP12 relative serum expression ≥2 | 2.421 | 0.548–10.695 | 0.243 |