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. 2016 Jul 19;16:19. doi: 10.1186/s12878-016-0059-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Bone marrow histopathologic findings confirming diagnosis of Hodgkin lymphoma. a Bone marrow biopsy demonstrated involvement by classical Hodgkin lymphoma. Neoplastic large lymphoid cells with Hodgkin-Reed-Sternberg morphology were present in a background rich in histiocytes, small lymphocytes, and plasma cells. b The neoplastic cells were positive for CD30. The neoplastic cells were also positive for the B-cell marker PAX5 by immunohistochemistry (not shown). c Colorimetric in situ hybridization was positive for Epstein-Barr virus-encoded RNA within the neoplastic cells (blue signal)