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Severity of grading and use of normal and abnormal laboratory values
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|
| Hemoglobin | 8.5–10.0 g/dL | 7.5–8.4 g/dL | 6.5–7.4 g/dL | <6.5 g/dL |
| Absolute neutrophil count | 1000–1300/mm3 | 750–999/mm3 | 500–749/mm3 | <500/mm3 |
| Platelets | 100,000–124,999/mm3 | 50,000–99,999/mm3 | 25,000–49,999/mm3 | <25,000/mm3 |
| Creatinine | 1.1–1.3 × ULN | 1.4–1.8 × ULN | 1.9–3.4 × ULN | ≥3.5 × ULN |
| Alanine aminotransferase | 1.25–2.5 × ULN | 2.6–5.0 × ULN | 5.1–10.0 × ULN | >10.0 × ULN |
ULN upper limit of normal
