Table 1.
Metabolic changes during supply ischemia protocol
| Baseline | Balloon occlusion 1 (BO1) | Balloon occlusion 2 (BO2) | ||||
|---|---|---|---|---|---|---|
| p value* | p value* | p value* | ||||
| GLP-1 (7–36) amide, pg/ml | ||||||
| Control | 2.9 ± 3.57 | – | 3.6 ± 4.13 | – | 2.9 ± 1.84 | – |
| GLP-1 only | 2.8 ± 1.43 | 0.51 | 2.5 ± 2.04 | 0.49 | 87.5 ± 37.1 | <0.001 |
| Glibenclamide only | 1.9 ± 1.66 | 0.46 | 1.1 ± 0.77 | 0.11 | 1.3 ± 0.54 | 0.07 |
| GLP-1 glibenclamide | 2.2 ± 0.59 | 0.57 | 2.3 ± 1.32 | 0.37 | 78.9 ± 31.1 | <0.001 |
| Insulin, pmol/L | ||||||
| Control | 79 ± 26 | – | 59 ± 29 | – | 58 ± 29 | – |
| GLP-1 only | 77 ± 52 | 0.91 | 63 ± 85 | 0.82 | 95 ± 64 | 0.16 |
| Glibenclamide only | 103 ± 93 | 0.51 | 292 ± 245 | 0.02 | 382 ± 297 | 0.02 |
| GLP-1 glibenclamide | 90 ± 51 | 0.63 | 412 ± 244 | <0.01 | 1133 ± 1089 | 0.03 |
| Glucose, mmol/l | ||||||
| Control | 5.1 ± 0.3 | – | 5.3 ± 0.3 | – | 5.4 ± 0.4 | – |
| GLP-1 only | 5.0 ± 0.3 | 0.83 | 5.0 ± 0.3 | 0.51 | 4.7 ± 0.3 | 0.20 |
| Glibenclamide only | 5.3 ± 0.3 | 0.66 | 6.3 ± 0.4 | 0.06 | 6.8 ± 0.4 | 0.02 |
| GLP-1 glibenclamide | 5.5 ± 0.3 | 0.44 | 5.9 ± 0.4 | 0.27 | 5.9 ± 0.7 | 0.45 |
| Free fatty acids, μmol/L | ||||||
| Control | 371 ± 364 | – | 1399 ± 973 | – | 1050 ± 637 | – |
| GLP-1 only | 473 ± 367 | 0.57 | 1213 ± 897 | 0.69 | 917 ± 516 | 0.64 |
| Glibenclamide only | 358 ± 201 | 0.93 | 633 ± 434 | 0.06 | 439 ± 248 | 0.02 |
| GLP-1 glibenclamide | 356 ± 183 | 0.91 | 846 ± 490 | 0.16 | 503 ± 307 | 0.04 |
| Dextrose infusion, mg kg−1 min−1 | ||||||
| Glibenclamide only | – | – | 1.69 ± 0.53 | – | 1.69 ± 0.53 | – |
| GLP-1 glibenclamide | – | – | 2.25 ± 1.6 | – | 2.44 ± 1.59 | – |
* p value compared with control group