Table 2.
Effects of TRPV4 antagonists on relaxant responses to noladin ether and arachidonic acid in mesenteric arteries
| pEC40% | Relaxation | n | ||
|---|---|---|---|---|
| 10 μM (%) | 30 μM (%) | |||
| Noladin ether (+ec) control | 6.2 ± 0.2 | 88 ± 4 | 10 | |
| + RN1734 | 6.1 ± 0.2 | 88 ± 4 | 5 | |
| + HC067047 | 6.1 ± 0.1 | 100 ± 4 | 4 | |
| + Ruthenium red | 5.4 ± 0.2 | 57 ± 5 | 4 ** | |
| Noladin ether (−ec) | 5.6 ± 0.1 | 61 ± 8 | 5 ** | |
| Arachidonic acid (+ec) control | 6.0 ± 0.1 | 87 ± 4 | 10 | |
| + HC067047 | 6.0 ± 0.2 | 82 ± 3 | 4 | |
| + Ruthenium red | 5.8 ± 0.1 | 93 ± 2 | 6 | |
Data represent mean ± SEM.
**
P < 0.01 versus corresponding control, as analysed by two‐way ANOVA of the whole data set, followed by Bonferroni post hoc tests.