Table 3.

Effects of cytochrome P450 inhibitors and KCl precontraction on relaxant responses to 2‐AG, noladin ether and GSK in mesenteric arteries

	pEC40%	Relaxation		n
		10 μM (%)	0.3 μM (%)
2‐AG (+ec) control	5.9 ± 0.2	89 ± 3		6
+ miconazole	5.9 ± 0.2	91 ± 6		5
+ SKF525A	5.4 ± 0.1	71 ± 5		6 **
KCl precontraction	—	−11 ± 12		4 **
Noladin ether (+ec) control	6.3 ± 0.2	88 ± 3		10
+ miconazole	6.2 ± 0.3	82 ± 6		5
+ SKF525A	—	58 ± 13		4 **
KCl precontraction	—	−1 ± 13		4 **
GSK (+ec) control	7.3 ± 0.1		79 ± 5	10
+ SKF525A	7.1 ± 0.2		80 ± 5	4 **
KCl precontraction	—		30 ± 9	6 **

Data represent mean ± SEM.

^** P < 0.01 versus corresponding control, as analysed by two‐way ANOVA of the whole data set, followed by Bonferroni post hoc tests.